It has emerged today that the US Food and Drug Administration (FDA) has recalled Lupin Pharma’s blood pressure-lowering drug perindopril for “not meeting specifications overtime”.
So far the drug maker, Lupin Pharma, has denied the recall.
In February this year, Lupin Pharma recalled 14,000 bottles of Lisinopril (the generic name for perindopril) 30 mg tablets from the US market, after safety concerns. The company received complaints about bottles of Lisinopril tablets also containing tablets of Lupin’s imipramine — a tricyclic antidepressant.
Perindopril is in a group of drugs called ACE inhibitors, or angiotensin converting enzyme inhibitors, which are primarily used to treat high blood pressure (hypertension) and to prevent heart attacks in people with coronary artery disease. However, it is also prescribed (off label use) to lower cholesterol.
Side effects associated with perindopril are: Arm or leg pain; back pain; cough; diarrhoea; dizziness; headache; runny nose; fatigue; chest pain; confusion; decreased, difficult, or painful urination; depression; difficulty swallowing; fast, slow, or irregular heartbeat; fever, chills, or sore throat and prolonged or severe nausea and vomiting; symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, yellowing of the skin or eyes); symptoms of low blood pressure (eg, fainting, severe dizziness, light-headedness); unusual tiredness or weakness; vision or speech problems.
Now if that’s not enough, if you happen to have a batch containing imipramine, you can also experience some of the following side effects: drowsiness; dry mouth; excitement; headache; impotence; nausea; nightmares; pupil dilation; sensitivity to sunlight; hallucinations; mental or mood changes; panic attacks; uncontrolled movements of arms and legs or stiffness; unusual bleeding or bruising; worsening of depression; yellowing of the skin or eyes.
If you are taking perindopril to control your blood pressure or cholesterol levels, contact your doctor as soon as possible and ask for alternative medication… Lupin Pharma may still be denying the recall, but with safety risks and side effects like those mentioned above, you’re better off not taking any chances. Better yet, use the information on The Cholesterol Truthto see if there aren’t safer alternatives to maintaining a healthy heart. You might benefit from reading the following related articles:
Until next time
The Cholesterol Truth
Here’s to a healthy heart
Bear in mind all the material in this email alert is provided for information purposes only. We are not addressing anyone’s personal situation. Please consult with your own physician before acting on any recommendations contained herein.
Lupin’s cholesterol-lowering drug Perindopril recalled in US; stock up, published online, 20.04.11, economictimes.indiatimes.com
Drugs.com – Side Effects: Perindopril and Imipramine, published online drugs.com